Andy Sachs returns to Runway as Miranda Priestly navigates a new media landscape and Runway's position within. The duo reconnect with former assistant Emily Charlton, now the head of a luxury brand that possesses funding which could ensure Runway's survival.

Meryl Streep
Miranda Priestly
Mary Louise "Meryl" Streep (born June 22, 1949) is an American actress. Often described as the best actress of her generation, Streep is particularly known for her versatility and accent adaptability. She has received numerous accolades throughout her career spanning over five decades, including a record 21 Academy Award nominations (winning three) and a record 32 Golden Globe Award nominations (winning eight). She has also received two British Academy Film Awards, two Screen Actors Guild Awards, and three Primetime Emmy Awards, in addition to nominations for a Tony Award and six Grammy Awards.

Anne Hathaway
Andy Sachs

Emily Blunt
Emily

Stanley Tucci
Nigel

Kenneth Branagh
Stuart

Justin Theroux
Benji Barnes

Lucy Liu
Sasha Barnes